PIAS4 and nervous system disorder: Specifically, Disc1 and Srcin1 are involved in spine maintenance and morphogenesis, respectively (Ingenuity P=0.00085 and 0.0034); Itga6 in neurite morphogenesis (P=0.00085); Gng7 and Soc5 in transmembrane signalling (P=0.0084 and P=0.025), Kif19 in microtubule dynamics (P=0.00338); whereas Disc1, Pias4, Rsrc1 and Frem have been implicated in autism, schizophrenia and neurological disorders.