PPARG and Schnyder corneal dystrophy: In the liver of NOX2−/−/HFD mice, the amount of both UCP-2 protein, which may help to decrease ATP and ROS formation40, and PPARγ, a transcription factor that upregulates Ucp-2 gene expression, was significantly lower than in WT/HFD mice and remained at about the same levels seen in WT/SCD mice.