COPS8 and Usher syndrome: SLC9A3R2, a scaffold protein not associated with ciliary function but which interacts with seven gold-standard proteins (Fig. 2b), interacts with known partners YAP1 and CTNNB1 plus several proteins involved in Usher syndrome and non-syndromic deafness and the COP9 signalosome (Fig. 2b) that hint at roles in actin attachment/polarization40, DNA damage response or proteasomal degradation41.