We also tested if alterations in the 14-3-3 adaptor proteins may also account for the effects of CAP1 depletion on cancer cell invasiveness; the CAP homologues in L.edodes and the fission yeast interact with the 14-3-3 protein37, and the sigma and Zeta isoforms of the 14-3-3 protein have been implicated in the invasiveness and proliferation of breast cancer38, 39. The gene discussed is YWHAQ; the disease is cancer.