Computerized image analysis of the slides stained with Mallory-Azan demonstrated that in HFD or MCD-fed mice showed an obvious accumulation of collagens, and treatment with IL-33 aggravated hepatic fibrosis induced by HFD (Figure 4a, 4b) or MCD (Figure 4a, 4d) in mice. Here, IL33 is linked to Hepatic fibrosis.