However, protein levels of the pro-apoptotic Mcl-1-specific BH3-only protein Noxa were markedly increased after treatment with L-asparaginase in SF188 cells - a finding also observed at lower concentrations of L-asparaginase in T98G and LN229 glioblastoma cells, indicating a potential cell type-specific response to L-asparaginase treatment. The gene discussed is PMAIP1; the disease is glioblastoma.