ASPG and glioma: As shown in Figure 3A, combined treatment with L-asparaginase and ABT263 yielded a synergistic anti-proliferative effect across a wide range of different pairs of concentrations tested in SF188, LN229, T98G, U251 glioblastoma cells and NCH644 glioma stem-like cells (Figure 3A, Table 1 and Supplementary Figure 2).