An analysis of the OncomiR target gene product expression found significant changes in the protein expression of DLBCL cells with acquired i-lncRNA expression; notably, the expression levels of tumor suppressor genes (PTEN, p27kip1, TIMP3, RECK) were upregulated, whereas those of oncogenes (p38/MAPK, survivin, CDK4, c-myc) were downregulated, suggesting that high-copy i-lncRNA expression protected the target genes of OncomiRs. The gene discussed is CDK4; the disease is diffuse large B-cell lymphoma.