After confirmed the interactions between OncomiRs and target genes, the DLBCL cells were infected adenovirus Ad5F35-i-lncRNA, consequently, the expression levels of PTEN, p27kip1, TIMP3, and RECK were upregulated in DLBCL cells, whereas the expression levels of p38/ MAPK, survivin, CDK4, and c-myc were downregulated (Figure 4B). The gene discussed is CDK4; the disease is diffuse large B-cell lymphoma.