In the cell model, we used human ESCC cells cultured from the CE48T cell line to analyze the efficacy of lapatinib, a HER2 inhibitor, and of foretinib (GSK1363089), a multikinase inhibitor of AXL, c-Met and VEGFR-2 [29]. The gene discussed is AXL; the disease is esophageal squamous cell carcinoma.