Our results showed that glioblastoma cells expressing OAcGD2 can be killed by mAb 8B6 by three different mechanisms in vitro: (1) induction of a non-immunologic direct cytotoxicity involving at least caspase-3, (2) induction of antibody-dependent cell cytotoxicity, and (3) induction of complement cellular cytotoxicity. This evidence concerns the gene CASP3 and glioblastoma.