EGFR and neoplasm: In a multivariable model after adjusting for age, gender, grade, tumor stage and the 3 biomarkers in which age, gender and grade were forced, membranous EGFR and membranous E-cadherin were significant independent predictors of LNM, respectively (P = 0.002 for E-cadherin and P < 0.001 for EGFR) (Table 2).