Genes significantly associated to Δsv-MALAT1 were mainly involved in cell migration (RHOB, PLAU/UPA and MMP14), Polycomb repressive complex PRC2 (EED, SUZ12, JARID2, TUG1), apoptosis (BIRC6), DNA repair (ATM, MSH2, XRCC1) and regulators (DGCR8) and interactors (SRSF1, SRSF3, UHMK1) of MALAT1. Genes involved in cell cycle control and EMT, as well as putative MALAT1-inducible genes (identified by MALAT1 depletion in cell lines) were not linked to the MALAT1 in breast cancer. The gene discussed is PLAU; the disease is breast cancer.