MTAP and central nervous system cancer: High frequency of MTAP deletion has been described in high-grade gliomas (Sasaki et al. 2003), namely in GBMs (Nakahara et al. 2004; Suzuki et al. 2004), in agreement with the present study, and also our recent report of MTAP protein expression in more than 85% of pilocytic astrocytomas (Becker et al. 2015b).