Besides the expected similar pattern of alterations described worldwide, the combination of our findings with in silico analysis of the Oncomine and TCGA data has led to the identification of genes for further investigation in glioma, such as CDK2, DMRTA1, MTAP, and IFN. This study contributes to the molecular profiling of astrocytomas, and constitutes an important step towards future personalized medical approaches for the treatment of patients diagnosed with astrocytomas. Here, MTAP is linked to central nervous system cancer.