Overall, it is important to understand the nature and breadth of Ltn1 substrates, as a mutation in the mouse LTN1 homolog, lister, results in a neurodegenerative disorder similar to spinal-bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS) (Chu et al. 2009). This evidence concerns the gene LTN1 and amyotrophic lateral sclerosis.