Immunohistochemistry (IHC) was nonspecific and inconsistent (positive for pancytokeratin, PAX8, and CDX2, and negative for CK7, CK20, ER, WT1, calretinin, CD31, CD34, and synaptophysin) and working diagnosis was a putative upper gastrointestinal versus mullerian cancer profile. The gene discussed is CALB2; the disease is cancer.