The network of ACSL1, ACSL4 and steraroyl-CoA desaturase-1 (SCD), which catalyzes the conversion of SFA into MUFA, is demonstrated to induce EMT program and the higher expression level of ACSL1/ACSL4/SCD is associated with the poorer survival outcome in colorectal cancer [81]. The gene discussed is ACSL1; the disease is colorectal cancer.