Re-sequencing and fine mapping of the region on CFA 26 associated with glioma identified three candidate genes; DENR, CAMKK2 and P2RX7 with the strongest associated SNV located within an intron of CAMKK2. Intriguingly, all three genes are potentially relevant candidate genes for cancer development and contain highly associated SNVs, offering the possibility that multiple variants contribute to disease at this extended locus. The gene discussed is P2RX7; the disease is cancer.