When excluding the 146 (4.6%) participants who had a prior myocardial infarction (35), stroke (28), non-AIDS cancer (42), liver cirrhosis or hepatic steatosis (42), or end-stage kidney disease (5), the hazard ratio for SNA/death among SMART and ESPRIT participants changed from 1.62 to 1.57 (95% CI: 1.31 to 1.87, p<0.001) per 2x higher baseline levels of IL-6 and D-dimer; associations between the IL-6 and D-dimer score and the risk of SNA events were similar for those with and without a history of prior SNA (p = 0.48 for the interaction). The gene discussed is IL6; the disease is myocardial infarction.