A previous report showed that CUEDC2 interacted with GADD34 and suppressed the activation of IKK, which is the upstream kinase of NF-κB, and that in turn suppressed pro-inflammatory cytokine production.11 Our study supports these previous results, and demonstrates that GADD34 is able to suppress sepsis, tissue injury, and macrophage activation after LPS stimulation through dephosphorylation of IKKβ in macrophages. This evidence concerns the gene NFKB1 and Sepsis.