IL1B and Sepsis: The symptoms of sepsis are fever, mental confusion, transient hypotension, diminished urine output, or unexplained thrombocytopenia.1 High levels of pro-inflammatory cytokines in serum, including tumor necrosis factor-α (TNFα), interleukin (IL) -6 (IL-6), IL-1, and IL-8, are a crucial feature of sepsis.1, 2, 3, 4, 5 Inflammation and multi-organ dysfunction are known to be closely related to sepsis-induced mortality.1, 2, 3 Despite robust previous research on the pathophysiology of sepsis, this syndrome remains the chief cause of death in intensive care units.1, 2, 4