PPP1R15A and Multiple Organ Failure: Severe sepsis exhibits high lethality due to cell and tissue damage and multiple organ failure.1 High amounts of inflammatory cytokines in serum are known to be associated with patient lethality in sepsis.1, 4, 5 GADD34 markedly lowered the lethality of LPS-exposed mice in association with reduced serum levels of pro-inflammatory cytokines (Figures 1a and b).