TLR3 ligation, induced experimentally through poly(I:C) stimulation, induced GADD34 to promote cytokine production, such as IFN-β and IL-6, through eukaryotic initiation factor 2α (eIF2α) dephosphorylation.23, 24 However, the role of GADD34 in innate immune responses against bacterial infection is still unclear. Here, PPP1R15A is linked to bacterial infectious disease.