The ability of HDL to inhibit NF-κB expression was higher in AMD patients (MD -5.6, 95% CI -9.5 to -1.8, p<0.05) (Fig 6B), even after adjusting for age, gender, BMI, CRP level, kidney and liver parameters, and HbA1c (p<0.05). Here, NFKB1 is linked to age-related macular degeneration.