In addition, the authors demonstrated that treatment of MM tumor-bearing SCID mice with IL-1R (Interleukin-1 receptor) antagonist (Anakinra) decreased the levels of IL-8 and VEGF in peritoneal lavage fluid, thus indicating that IL-1 has a key role in regulating the production of other cytokines, thus affecting the tumorigenesis of mesothelial cells [63]. This evidence concerns the gene IL1A and neoplasm.