Cioce et al. showed that butein (3,4,2′,4′-tetrahydroxychalcone), a natural inhibitor of NF-κB and STAT-3, inhibits the migration of MM cells and strongly affects the clonogenicity of MM cells in vitro by inhibiting the phosphorylation of STAT-3, the nuclear localization of NF-κB and the interaction of NF-κB and phospho-STAT-3. Here, STAT3 is linked to Miyoshi myopathy.