Our data, in line with previous studies [8–13], indicate that in TSC patients there is an age-related LAM prevalence, a higher frequency of TSC2 mutations (statistically borderline in our study) [11, 35, 36], and more frequent occurrence of renal [10, 11, 22] and hepatic angiomyolipomas [37]. This evidence concerns the gene TSC2 and lymphangioleiomyomatosis.