Increased levels of TGF-β1 were associated with increasing risk of death from pancreatic cancer [40], shorter overall survival [65] and advanced disease stage in some studies [22, 33, 57], while in others studies a lower concentration was correlated with longer patient survival [33] (Table 3) and response to therapy [33, 65] (Table 4). The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.