The radical prostatectomy outcomes of another large cohort of 919 PCa men who met a strict criteria for AS after TRUS biopsy (cT1c, PSA <10 ng/mL, a single positive biopsy, tumour length <3 mm, and Gleason score < 6) were similar to Mitsuzuka’s findings: GS was upgraded in 34% of men (1% presented GS 8–9), 11% of men had pT3 disease, and 1% had pT4, while 26% of men were found to have insignificant tumours [13]. The gene discussed is KLK3; the disease is posterior cortical atrophy.