AKT1 and hereditary clear cell renal cell carcinoma: Besides, RACK1 can modulate PI3K/Akt signaling or activates Akt to propel cell proliferation and invasion/metastasis in VEGF/Flt1-mediated endothelial cells [26], mouse hepatocarcinoma cells [27], renal cell carcinoma [28], and some other cancers [29, 30].