Despite these differences, numerous apoptotic and pro‐survival genes were specifically downregulated in vivo upon combined BRAF and BET treatment, including the anti‐apoptotic proteins BCL2, BCL‐XL, and MCL1, and the survival factors AKT1 and HDAC1. The BCL‐2 family of proteins has shown to influence both the progression and chemotherapeutic response of melanoma 29. This evidence concerns the gene HDAC1 and melanoma.