TNF and Increased total eosinophil count: Mice knock-out for Dok1 were hypersensitive to LPS showing high levels of TNFα and NO [48] while triple KO mice (Dok1-2-3) showed spontaneous pulmonary inflammation, with hallmarks of asthma, including eosinophilia, goblet cell hyperplasia, and subepithelial fibrosis [50].