PTPRC and neoplasm: While it is unclear why single-arm treatments did not increase TILs, the higher baseline of CD45+ cells in the EMT-6 model (46.0 %) compared with the E0771 model (11.6 %) may suggest a higher percentage of myloid derived supressor cells (MDSC) or Tregs in the EMT-6 tumor microenvironment that single-arm treatments are unable to overcome.