The absence of profound overt phenotypes in both juvenile and aging C4.4A-deficient mice is considered beneficial for the future use of these animals in studies aiming at elucidating the possible impact of C4.4A-expression on the progression of lung adenocarcinomas whether these lesions are induced genetically or by external exposure to carcinogens. The gene discussed is LYPD3; the disease is lung adenocarcinoma.