In Case 2, with IUGR, joint contractures, mild hydrocephalus and decreased fetal movements, the fetus was found to be compound heterozygous for two missense variants/mutations of the NEB gene: a novel c.11060C > T (p.Ala3687Val) variant/mutation not present in public databases and a c.11333T > C (p.Ile3778Thr) variant/mutation present in the ExAc database with an allele frequency of 9.113e−05, both predicted as probably pathogenic. The gene discussed is NEB; the disease is Hydrocephalus.