PROKR2 and heart septal defect: The couple and their obstetrician requested further testing through Fetalis, where it was found that the fetus harbored a heterozygous PROKR2 c.518T > G (p. L173R) known pathogenic mutation, previously reported in several Kallmann syndrome patients (Sarfati et al., 2010; Sarfati et al., 2013), frequently presenting with septal heart defects.