PTPN11 and cancer: Six mutations had been previously reported in cancer, NRAS, p.G12S (n=2), FLT3LG pQ114fs (n=2), FLT3 p.N676K and PTPN11 p.A72T; three mutations were novel, RASGRP3 p.E445K, NF1 p.P1667S and CBL p.E113Q.