CLOCK and cardiovascular disorder: The occurrence of heart attacks and strokes exhibit a daily rhythm[7] and the importance of the relationship between cardiovascular disease and circadian rhythms can be directly demonstrated in mice with genetic disruption of the circadian clock which results in impaired endothelium-dependent relaxation [8], exaggerated vascular remodeling [9, 10], altered cardiac ischemia reperfusion [11] increased atherosclerosis [12, 13], and impaired blood pressure control [14].