IRS1 and metabolic dysfunction-associated steatotic liver disease: SNPs more specifically involved in NAFLD development and progression include e.g. variants in insulin receptor substrate-1 (IRS1) and glucose transporter solute carrier family 2 member 1 gene (SLC2A1) [20–22], while AFLD is associated with allelic variations in class I alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) [23].