As presented in Fig. 4, the integrative analysis of –omics data provided a fairly comprehensive molecular phenotype underlying the pleiotropic effects of IL-8 function: The up-regulation of IL-8 in the T24M cells was associated with an up-regulation of matrix metalloproteases (MMP2), implicated in tumor invasion37, as well as VEGFC and ICAM1, factors implicated in angiogenesis38, 39 (Fig. 4). This evidence concerns the gene ICAM1 and neoplasm.