NDUFA13 and neoplasm: Interestingly, GRIM-19 expression is independent of patients' gender, age, tumor differentiation and Lauren's histologic type, whereas lack of GRIM-19 significantly correlated with aggressive clinicopathologic features of GC patients including advanced clinical stage, lymph node metastasis, and H. pylori infection (Table 1), indicating that loss of GRIM-19 is associated with poor clinical outcomes of GC patients.