To study the biological effects of OTUB1 on ovarian cancer, we first confirmed the oncogenic functions of OTUB1 on cell proliferation in vitro (Supplementary Figure 6A-6D), which was further identified in the in vivo xenograft models (Supplementary Figure 6G); OTUB1 also promoted cell migration and invasion in vitro (Supplementary Figure 6E-6F). The gene discussed is OTUB1; the disease is ovarian cancer.