Survivin was the highest ranking IAP in all untreated cell lines (rank 62-92) and remained important under KIT inhibition in GIST882 and GIST430-654 (ranks 304 and 110, respectively) In GIST-T1, survivin proved less essential under KIT inhibition (rank 1614). The gene discussed is KIT; the disease is gastrointestinal stromal tumor.