Tumor stroma-derived epidermal growth factor (EGF), one of its most crucial ligands, has been implicated in this metastatic potential, predominantly in terms of cell migration through downstream signaling pathways, such as the MAPK/ERK and PI3K/AKT pathways [22], and EGF-induced chemotaxis of invasive cells to blood vessels is an essential step of metastasis. Here, EGF is linked to neoplasm.