In summary, our findings indicate that increased miR-363 expression is a frequent event in gastric cancers and increased miR-363 expression promotes cell proliferation, chemo-resistance by inhibiting the FBW7 pathway, suggesting that targeting miR-363 in a subset of gastric cancer would be an optimal therapeutic strategy and miR-363 may be a biomarker for predicting responsiveness to chemotherapy treatment. Here, FBXW7 is linked to gastric cancer.