F-box and WD repeat domain-containing 7 (FBW7) is a substrate recognition component of the Skp1-Cul1-F-box (SCF) ubiquitin ligase complex and functions as a tumor suppressor by ubiquitination and degradation several oncoprotein proteins, including c-Myc, cyclin E, Notch-1, c-Jun, and Mcl-1, thus participating in inhibiting the progression of cancer [16–18]. The gene discussed is FBXW7; the disease is cancer.