It has been confirmed that PKM2 plays a role in tumor anabolic metabolism [30] For example, knockdown of PKM2 suppressed aerobic glycolysis of liver cancer cell [31] In this study, we found that double mutant P53 (N340Q/L344R) enhanced the pyruvate kinase M2 isoform (PKM2) activity. The gene discussed is TP53; the disease is neoplasm.