Ultimately, P53 (N340Q/L344R) accerlerates the growth of hepatocellular carcinoma cells by activated telomerase and prolonged telomere through the cascade of P53 (N340Q/L344R) -CUDR-PKM2-pH3T11- (H3K9me1-HP1α)-Pim1- (TERT-HOTAIR-TERRA). Here, TP53 is linked to hepatocellular carcinoma.