In fact, PKM2 is required for cell survival and proliferation in tumorigenesis [32, 33] Moreover, the PKM2 dimers and tetramers are critical for tumorigenesis and epithelial-mesenchymal transition which is controlled by multiple factors, e.g. miR675 and H19 [34, 37] It is worth noting that our findings in this study provide novel evidence for an active role of PKM2 based on double mutant P53 (N340Q/L344R) in liver cancer cell growth. Here, PKM is linked to liver cancer.