Tau hyperphosphorylation causes its pathological aggregation and loss of its physiological function (Johnson and Stoothoff, 2004); resulting in the formation of neurofibrillary tangles (NFTs), a hallmark of a number of neurodegenerative diseases termed as tauopathies, including Alzheimer’s disease (AD) (Lee et al., 2001). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.