MAPT and Neurofibrillary tangles: In accordance with the histopathological progression of AD, htau mice display an age-related increase of hyperphosphorylated tau in cortical and hippocampal areas; somatic redistribution of tau, indicated by the presence of insoluble tau in dendrites, as early as at two months of age and accumulation of phosphorylated tau in the cell body at three months of age; tau aggregates are observed by nine months of age, resembling later stage NFTs in humans (Andorfer et al., 2003).