Although hepatic caspase-3/7 activity was not significantly increased (Figure 3D), combining OZ with nelfinavir was more efficacious compared to OZ monotherapy in the orthotopic model (number of macroscopic nodules per liver: 11.1 ± 3.9 after OZ versus 7.2 ± 5.2 after OZ and nelfinavir; microscopic tumor burden: p < 0.05; Figure 3A–3C). The gene discussed is CASP3; the disease is neoplasm.