Recently, it has been identified as an intracellular enzyme and called nicotinamide 5-phosphoribosyl-1-pyrophosphate transferase (NAMPT) that catalyzes the rate-limiting step in nicotinamide adenine dinucleotide (NAD) biosynthesis and mediates the conversion of nicotinamide to nicotinamide mononucleotide [7–9].It has been proposed that this adipose derived hormone exerts insulin mimicking effects and play a positive role in attenuating insulin resistance. The gene discussed is NAMPT; the disease is Insulin resistance.