Several mutations were affecting genes such as GRID2, DMD and RAB39B that are known to be risk factors for ID, neuromuscular disorder, epilepsy and in some cases ASD.73, 77, 78, 79, 80 It would now be interesting to ascertain if patients with some genetic backgrounds are more sensitive to CNTN6 mutations. The gene discussed is CNTN6; the disease is epilepsy.