Although we found a strong correlation between sHSP27 and pVEGF, sVEGF as well as s-bFGF in blood samples taken before treatment with bevacizumab, there was no association between tissue expression of HSP27 in metastases and sHSP27, similar to a previous study on breast cancer [44], and no relationship between blood levels of these factors and response to treatment. The gene discussed is FGF2; the disease is breast cancer.