Thus, in sharp contrast to DRB1*09:01 (which also has been reported to be associated with predisposition to RA [20,21], SLE [21], type 1 diabetes [22], and myasthenia gravis [23]), DRB1*13:02 or other allele(s) in strong LD appears to have a protective effect against multiple autoimmune rheumatic diseases. This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.