In a mouse model of colitis-associated colon cancer (CAC) in which a single injection of azoxymethane (AOM) is followed by multiple treatments of DSS in the drinking water, we found that P1-HNF4α is greatly reduced in tumors compared to untreated controls but that total HNF4α protein was only marginally reduced (Figure 2D), suggesting that P2-HNF4α was not affected. This evidence concerns the gene HNF4A and colonic neoplasm.