However, AMPK suppresses cell proliferation via inhibition of mTOR and activation of p53 pathways (Motoshima et al., 2006) and low levels of AMPK activity are correlated with poor survival in metastatic colon cancer patients (Zulato et al., 2014), indicating that additional studies are required to elucidate the impact of AMPK signaling on HNF4α in colitis and colon cancer. This evidence concerns the gene HNF4A and malignant colon neoplasm.