EMD and neoplasm: For example, NDRG2, a kinase downstream of the mTOR/SGK pathway and a tumor suppressor that mediates apoptosis (Deuschle et al., 2012), and EMD, a nuclear membrane protein phosphorylated by Src (Tifft et al., 2009), both preferentially bind HNF4α1 and have been negatively associated with colon cancer.