Even though both promoters are expressed in adult intestines (Tanaka et al., 2006; Nakhei et al., 1998; Briançon and Weiss, 2006) and HNF4α has been implicated in human colon cancer (Chellappa et al., 2012; Tanaka et al., 2006; Oshima et al., 2007; Cancer Genome Atlas Network, 2012; Zhang et al., 2014) and colitis (Ahn et al., 2008; Barrett et al., 2009; Fang et al., 2011), the distribution and function of the different HNF4α isoforms in the colon have not been investigated until now (results summarized in Figure 7E). Here, HNF4A is linked to malignant colon neoplasm.