Assessment of endogenous HTRA3 expression revealed that the long isoform (HTRA3-L) was expressed at higher levels in normal human small airway epithelial cells (SAECs) than in lung cancer cell lines, whereas the expression of the short isoform (HTRA3-S) did not differ significantly between normal and cancerous cells(Supplementary Figure 2). The gene discussed is HTRA3; the disease is lung cancer.