Amazingly, a single miRNA could affect numerous of target genes coincidently [43], for instance, it has been reported that miR-134 suppresses progression of melanoma by down-regulating CD86 [25]; and miR-134 could modulate resistance to doxorubicin in human breast cancer cells by repressing ABCC1 oncogene [27]. This evidence concerns the gene ABCC1 and melanoma.