CASP3 and lung cancer: In addition, inhibition of CCND1 expression promoted apoptosis in lung cancer cell (4.5-fold of increase or 3.4-fold of increase in caspase 3 activity, 2.1-fold of increase or 2.3-fold of increase in caspase 7 activity inA549 or SPC-A-1 cells) (Figure 4J–4K).