Basing on the clues above, we hypothesized that: (1) expression of ZNRD1-AS1 was up-regulated and expression of ZNRD1 was down-regulated in lung cancer tissues; (2) Cis-eQTL loci in LncRNA ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) contribute to the development of lung cancer. The gene discussed is POLR1H; the disease is lung carcinoma.