Consistent with these results, we found miR-146b-5p was down-regulated in GSCs compared to non-GSCs glioma cells and its overexpression could suppress stemness and radioresistance of GSCs by targeting HuR, which was verified as a miR-146b-5p target in GSCs by bio-informatic analysis, real-time PCR, and luciferase reporter assay in the present study. Here, ELAVL1 is linked to glioma.